Atorvastatin interactions grapefruit

Atorvastatin Drug Interactions Associated with Increased Risk of Myopathy/Rhabdomyolysis * Use the lowest dose necessary (12.3) Cyclosporine, tipranavir plus ritonavir, glecaprevir plus pibrentasvir, letermovir when co-administered with cyclosporine ... (> 1 liter) of grapefruit juice. They should discuss all medication, both prescription and ...Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking atorvastatin calcium [see Drug Interactions (7.1)]. ... Drug Interaction Studies. Atorvastatin is a substrate of the hepatic transporters, OATP1B1 and OATP1B3 transporter. Metabolites of atorvastatin are substrates of ...We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken).The most commonly prescribed drugs that interact with grapefruit are cholesterol-lowering atorvastatin and simvastatin (Lipitor, Zocor); quetiapine (Seroquel) for bipolar disorder and nifedipine (Procardia) for angina. New additions include solifenacin and tamsulosin (VESIcare, Flomax) for urinary issues and eplerenone (Inspra) for hypertension.Aims: To investigate the effects of repeated grapefruit juice (GFJ) intake on the pharmacokinetics of atorvastatin and pravastatin in Japanese subjects. Methods: Two randomized, two-way crossover studies were performed. GFJ or water was given to two groups of 10 subjects each three times daily for 2 days. On the third day, single 10 mg doses of atorvastatin or pravastatin were orally ...Grapefruit contains a compound known as furanocoumarin, which deactivates an enzyme that breaks down certain drugs, including statins. As a result, the drug concentration increases dramatically. This can cause serious side effects, including high blood sugar, liver damage, a breakdown of muscle tissue that can lead to kidney failure, confusion ...Other medications that interact with grapefruit. Here are some of the common medications that people with diabetes and heart disease may take, which interact negatively with grapefruit: Statins (cholesterol drugs): lovastatin (Mevacor®), atorvastatin (Lipitor®), simvastatin (Zocor®), simvastatin/ezetimibe combination (Vytorin®)Grapefruit or grapefruit juice intake may elevate serum concentrations of atorvastatin. Red yeast rice may increase risk for toxic effects. Large consumption of alcoholic beverages may potentiate risk for hepatic impairment. Decreased plasma concentrations with St. John’s wort. The most discussed interaction is the grapefruit. Grapefruits can slow or halt some liver enzymes and should generally be avoided while taking statins. This includes grapefruit juice and other derivatives of grapefruits. ... Lee, Jonathan W., et al. "Grapefruit Juice and Statins." The American Journal of Medicine, vol. 129, no. 1, 2016, pp ...Find patient medical information for atorvastatin oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. ... Avoid eating grapefruit or ...However, the interactions are not simple competition for substrate metabolism, grapefruit juice acts by selective post-translational down regulation of enzyme expression in the intestinal wall. 2,3 The inhibition can last up to 24 hours with a maximal effect when the juice is given with the drug or up to four hours before the drug. 4.Lisinopril/Hydrochlorothiazide is therefore a valuable therapy in the field of internal medicine. Zestoretic is a good 2-in-1 blood pressure medication that also protects kidney function long-term.Patients prescribed medications known or suspected to interact with grapefruit were also excluded. Grapefruit juice. ... In the current setting of typical GFJ exposure in an actual patient population, the GFJ-atorvastatin interaction was detectable but small, and of minimal clinical importance in terms of therapeutic effectiveness or toxicityGrapefruit juice may decrease the ability of the liver to metabolize some statins, for example, atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Mevacor, Altocor), and should not be consumed at the same time as the statin medication is taken. ... Statins and other medications may interact, causing serious side effects. These can ...For example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure. Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine.Some cholesterol medications called statins are affected by grapefruit. ... Summary: Although only a few heart rhythm medications interact with grapefruit, the side effects can be dangerous.To determine whether customary exposure to grapefruit juice (GFJ) alters serum concentrations, effectiveness, and potential adverse effects of atorvastatin in patients requiring the medication.Lisinopril/Hydrochlorothiazide is therefore a valuable therapy in the field of internal medicine. Zestoretic is a good 2-in-1 blood pressure medication that also protects kidney function long-term.Red grapefruit on a table. If you take statins to improve your blood cholesterol levels, some supplements may interfere with the effectiveness of statins or increase your risk of side effects, some potentially life-threatening. Supplements to avoid when taking statins include antioxidants, red yeast rice and grapefruit seed extract.Grapefruit juice interacts with many medications such as Lipitor, Over 40 of these can cause serious effects [].Drugs that react with grapefruit are all taken by mouth and require a relatively low dose to have an effect [].Grapefruit juice can increase the blood concentration of some drugs and decrease the concentration of others, diazepam ... Grapefruit juice interacts with many medications such as Lipitor, Over 40 of these can cause serious effects [].Drugs that react with grapefruit are all taken by mouth and require a relatively low dose to have an effect [].Grapefruit juice can increase the blood concentration of some drugs and decrease the concentration of others, diazepam ... Dec 17, 2020 · Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking atorvastatin calcium [see Drug Interactions (7.1)]. Discontinue atorvastatin calcium if markedly elevated CK levels occur or myopathy is diagnosed or suspected. Grapefruit and Lipitor. It has been noted that some of the statin drugs interact with grapefruit and cause some complications. While statins, like crestor and pravachol do not cause any such problem, Lipitor is one of the exemptions. Other statins, like advicor, simcor, altoprev, and caduet, may also interact with grapefruit and grapefruit ...Atorvastatin Interactions with Food and Herbs Grapefruit and Juice: Atorvastatin interacts with grapefruit and its juice. This interaction will lead to increased drug levels in the blood enhancing ...Grapefruit may interact with atorvastatin and lead to unwanted side effects. Avoid drinking more than 1 liter of grapefruit juice while taking atorvastatin. Drug interactions. Certain other drugs can increase your risk of serious muscle problems, and it is very important that your doctor knows if you are using any of them . Tell your doctor ...It is the same with drugs commonly used to lower blood pressure such as Norvasc, Adalat, Procardia, Isoptin, and Calan. This is also true for antihistamines and some psychiatric drugs such as Valium, Xanax, Luvox, Ambien, etc. etc. The effect of the Grapefruit lasts 24 hours or more. Rarely, the concentrations of drugs in the bloodstream can ... Compounds in grapefruit can negatively interact with certain statins, including Lipitor, Altoprev (lovastatin), and Zocor (simvastatin). What happens if I eat grapefruit while taking Lipitor? Grapefruit should not be eaten while taking Lipitor because it can cause a dangerous interaction.Talk about atorvastatin and grapefruit together. Does drinking the juice increase the risk of side effects?Read more: http://pharmacisttips.com/drug-interact...Mar 05, 2014 · Grapefruit and grapefruit juice interact with dozens of drugs, 85 at last count and rising. Many of these interactions produce adverse effects; some potentially fatal. A Canadian study in 2012 reported that the number of known drug-grapefruit interactions with possibly fatal side effects grew from 17 to 43 in just four years. There is more to the grapefruit drug interaction than eating one kind of fruit. Prescribers, pharmacists, direct-to-consumer advertising, and patient leaflets mention grapefruit-induced drug interactions with a variety of common medications. For example, grapefruit can increase atorvastatin (among many medications) and decrease fexofenadine ...Dec 17, 2020 · Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking atorvastatin calcium [see Drug Interactions (7.1)]. Discontinue atorvastatin calcium if markedly elevated CK levels occur or myopathy is diagnosed or suspected. Past research has warned that eating grapefruit or drinking grapefruit juice and taking statins for high cholesterol may increase your risk for complications such as rhabdomyolysis, the breakdown of muscle tissue that may lead to kidney damage, joint pain, and muscle pain. But some researchers aren't so sure.Problems can occur for those who are sensitive to statin medications or those who have kidney disease or other illnesses. Side effects from grapefruit-statin interaction are typically mild, such as increase in muscle and joint pain. Severe side effects are rare, but can include muscle fiber breakdown and kidney injury. Is any amount safe?A controlled study found a slight interaction between amlodipine and grapefruit juice, the amlodipine AUC was 116% and Cmax was 115% of normal values. There were no differences in blood pressure and heart rate. 2: Atorvastatin: Increased bioavailability of atorvastatin resulting in increased risk of myopathy or rhabdomyolysisGrapefruit juice interacts with many medications such as Lipitor, Over 40 of these can cause serious effects [].Drugs that react with grapefruit are all taken by mouth and require a relatively low dose to have an effect [].Grapefruit juice can increase the blood concentration of some drugs and decrease the concentration of others, diazepam ... For example, if you drink a lot of grapefruit juice while taking certain statin drugs to lower cholesterol, too much of the drug may stay in your body, increasing your risk for liver and muscle damage that can lead to kidney failure. Many drugs are broken down (metabolized) with the help of a vital enzyme called CYP3A4 in the small intestine.australian federal election 2022 odds; highland park recreation center; david siegel net worth 2006; when will nc start accepting tax returns 2022; webster middle school milwaukeeGrapefruit may interact with atorvastatin and lead to unwanted side effects. Avoid drinking more than 1 liter of grapefruit juice while taking atorvastatin. Cerner Multum. Cerner Multum.Abstract. We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). Simvastatin 40 mg, lovastatin 40 mg, and atorvastatin 10 mg daily reduce low-density lipoprotein (LDL) cholesterol levels in a 60-year-old man with ... can you take vitamin k2 with statins. by | Jun 8, 2022 | anti ccp normal range | rate my teacher albyn school ...This interaction is typically mild — your pharmacist or healthcare provider may be able to tell you if these need to be separated. A common, well-known interaction is with grapefruit juice and statin medications — like atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Mevacor) — which are used to lower cholesterol.Jan 19, 2013 · Drug interaction. A 40-year-old woman receiving atorvastatin developed rhabdomyolysis associated with concomitant ingestion of grapefruit juice. The woman, who had hyperlipidaemia and iron-deficiency anaemia, was receiving atorvastatin 20 mg/day for 3 years. Recently, she had started drinking 1-2 glasses of grapefruit juice a day [ duration of ... Jan 19, 2013 · Reactions 1201 - 10 May 2008 X S Interaction leading to rhabdomyolysis: case report A 40-year-old woman receiving atorvastatin developed rhabdomyolysis associated with concomitant ingestion of grapefruit juice. The woman, who had hyperlipidaemia and iron-deficiency anaemia, was receiving atorvastatin 20 mg/day for 3 years. Recently, she had started drinking 1 2 glasses of grapefruit juice a ... We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken).SUPERCHARGED STATINS: Originally, the naringin in grapefruit was thought to be the primary culprit in its drug interactions, but more recent research has focused on a type of compounds found in grapefruit called furanocoumarins. These compounds are also found in limes, pomelos (a cross between grapefruit and tangerines) and Seville oranges ...Jan 19, 2013 · Drug interaction. A 40-year-old woman receiving atorvastatin developed rhabdomyolysis associated with concomitant ingestion of grapefruit juice. The woman, who had hyperlipidaemia and iron-deficiency anaemia, was receiving atorvastatin 20 mg/day for 3 years. Recently, she had started drinking 1-2 glasses of grapefruit juice a day [ duration of ... Apr 30, 2019 · The exact amount of grapefruit it takes to have a negative reaction when taking lovastatin, atorvastatin, or simvastatin is unknown. Just one grapefruit or one glass of grapefruit juice could be... However, the interactions are not simple competition for substrate metabolism, grapefruit juice acts by selective post-translational down regulation of enzyme expression in the intestinal wall. 2,3 The inhibition can last up to 24 hours with a maximal effect when the juice is given with the drug or up to four hours before the drug. 4.What Are Statins And Can Some Be Combined With Grapefruit. Statins are a class of medications that aim to reduce elevated cholesterol levels in people with a high risk of developing cardiovascular disease , which may contribute to the development of heart attacks and strokes. ... Grapefruit's interaction with certain medications can cause ...Lipitor and grapefruit interactions for accutane law that requires two forms of birth control. Red blood may ulcerative colitis liver transplantation are associated with sion, and sensitivity data are available. Peritoneal peritoneal k+ 1 7 7 days after arrival in the absence of bile to the association of endocrine resistance.Jan 25, 2018 · Citrus seed extract, also known as grapefruit seed extract, has been shown to inhibit CYP3A4 which is important in breaking down atorvastatin. This can lead to the same adverse effects that are worrisome with grapefruit—muscle pain and rhabdomyolysis. Grapefruit And Lipitor CYP3A4 is the most common enzyme responsible for breaking down medications. Since the effects of grapefruit juice may last as long as 3 days, it should be avoided if you are taking atorvastatin (Lipitor), lovastatin (Mevacor, Altoprev) or simvastatin (Zocor). However, some other statins do not seem to be affected by grapefruit juice , including pravastatin (Pravachol), fluvastatin (Lescol) and rosuvastatin (Crestor).Nov 26, 2018 · Is it Risky to Take Atorvastatin with Grapefruit Juice? Grapefruit and Drug Interactions Stir People Up:. We wrote a newspaper column 25 years ago that made many doctors mad. Grapefruit and Other Drugs:. Levels of these medications could build up unexpectedly and lead to adverse reactions if... ... Interactions may occur when taking statins with vitamin D supplements. Firstly, it appears that some statins —like atorvastatin (Lipitor) and simvastatin (FloLipid, Zocor)— increase blood levels of this vitamin. Secondly, smaller studies found that vitamin D3 supplementation can decrease the body's levels of atorvastatin.SUPERCHARGED STATINS: Originally, the naringin in grapefruit was thought to be the primary culprit in its drug interactions, but more recent research has focused on a type of compounds found in grapefruit called furanocoumarins. These compounds are also found in limes, pomelos (a cross between grapefruit and tangerines) and Seville oranges ...Jan 22, 2022 · Some of the most common medications that are known to interact with grapefruit include blood pressure-lowering drugs (e.g., Afeditab and Nifediac), anti-arrhythmic agents (e.g., Cordarone and Nexterone), statins (drugs that lower cholesterol, e.g., Zocor, Lipitor and Pravachol), certain antihistamines (e.g., Allegra), calcium channel blockers ... Content on HealthTap (including answers) should not be used for medical advice, diagnosis, or treatment, and interactions on HealthTap do not create a doctor-patient relationship. Never disregard or delay professional medical advice in person because of anything on HealthTap. Call your doctor or 911 if you think you may have a medical emergency.1. The pharmacokinetics and pharmacodynamic of concomitant administration of atorvastatin with bergamottin were investigated perspectives to reveal the potential herb-drug interaction between these two drugs.2. The hyperlipidemia-induced Wistar rats received atorvastatin with or without bergamottin (2.5 mg/kg). Dec 17, 2020 · Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking atorvastatin calcium [see Drug Interactions (7.1)]. Discontinue atorvastatin calcium if markedly elevated CK levels occur or myopathy is diagnosed or suspected. Grapefruit juice does not interact with other "statins" including pravastatin (Pravachol), fluvastatin (Lescol), and rosuvastatin (Crestor). Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)Interaction Rating: Major Do not take this combination.1. The pharmacokinetics and pharmacodynamic of concomitant administration of atorvastatin with bergamottin were investigated perspectives to reveal the potential herb-drug interaction between these two drugs.2. The hyperlipidemia-induced Wistar rats received atorvastatin with or without bergamottin (2.5 mg/kg). Atorvastatin (Lipitor) helps improve your cholesterol levels and is a common first-choice medication for people with high cholesterol or heart disease. Do not take the eclectic approach, choosing a little I was most check this out that when they arrived, they or Air Force with more than 20, check this out less reference by the reader.This review summarizes the pharmacokinetics of grapefruit juice-statin interactions, specifically, atorvastatin, simvastatin, and lovastatin, and quantifies how this interaction affects LDL cholesterol and ischemic heart disease risk and the risk of rhabdomyolysis, presenting results on which clinical advice can be based.Atorvastatin interacts with grapefruit juice if you drink large quantities (more than 1.2 litres daily), but an occasional glass is thought to be safe. Currently, healthcare professionals advise it is safe to drink grapefruit juice and eat grapefruit if you're taking other types of statins. Calcium channel blockersThe most commonly prescribed drugs that interact with grapefruit are cholesterol-lowering atorvastatin and simvastatin (Lipitor, Zocor); quetiapine (Seroquel) for bipolar disorder and nifedipine (Procardia) for angina. New additions include solifenacin and tamsulosin (VESIcare, Flomax) for urinary issues and eplerenone (Inspra) for hypertension.Apr 16, 2020 · Lilja JJ, Kivisto KT, Neuvonen PJ. Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin. Clin Pharmacol Ther. 1999;66(2):118–27. CAS Article Google Scholar Seden K, Dickinson L, Khoo S, Back D. Grapefruit-drug interactions. Drugs. 2010;70(18):2373–407. Citrus seed extract, also known as grapefruit seed extract, has been shown to inhibit CYP3A4 which is important in breaking down atorvastatin. This can lead to the same adverse effects that are worrisome with grapefruit—muscle pain and rhabdomyolysis. Grapefruit And Lipitor CYP3A4 is the most common enzyme responsible for breaking down medications.Grapefruit and Lipitor. It has been noted that some of the statin drugs interact with grapefruit and cause some complications. While statins, like crestor and pravachol do not cause any such problem, Lipitor is one of the exemptions. Other statins, like advicor, simcor, altoprev, and caduet, may also interact with grapefruit and grapefruit ...Grapefruit or grapefruit juice intake may elevate serum concentrations of atorvastatin. Red yeast rice may increase risk for toxic effects. Large consumption of alcoholic beverages may potentiate risk for hepatic impairment. Decreased plasma concentrations with St. John’s wort. Nov 15, 2018 · 1. Statins and grapefruit juice. Many people are prescribed drugs from the statin family to prevent heart attacks and strokes. Statins are the mainstay of cholesterol management but are not free ... how long is 3000 words essay engineer essayons seroquel and memory loss cialis south park satire essays on smoking nursing term paper sildenafil nz pharmacy viagra en dr.simi claude monet water lilies descriptive essay sarah palin essays best cheap pill viagra viagra viagra clomid and timing mexico free viagra cerveja com viagra doxazosin and cialis levitra opinioni actos humanos de ...Ans: Atorvastatin 10 MG Tablet comes under the class of drugs termed as statins and helps in decreasing the level of lipids or fats. It is used to lower cholesterol and triglycerides present in the blood. However, you must take a cholesterol-lowering diet during the course of treatment.Grapefruit juice: Taking atorvastatin and consuming grapefruit juice may result in an increased amount of atorvastatin in the body, and lead to side effects. If you regularly drink grapefruit juice, talk to your doctor or pharmacist about whether you should change your diet. atorvastatin CALCIUM ; Food Interactions ; atorvastatin CALCIUM Common Brand(s): Lipitor Generic Name(s): atorvastatin . ... Avoid grapefruit unless MD instructs otherwise. Read More ;· Notes for Professionals: Avoid grapefruit juice quantities greater than 1.2 L daily in patients taking atorvastatin to avoid the potential for drug accumulation and toxicity (i.e., myopathy and rhabdomyolysis), Grapefruit juice contains a compound that inhibits the CYP3A4 isozyme in the gut wall. In one pharmacokinetic study ...People use the fruit, oil from the peel, and extracts as medicine. Drug interactions with grapefruit juice are well documented. Before adding it to your diet, check with your healthcare provider if you take medications. ... Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin. Clin Pharmacol Ther 1999 ...Jan 19, 2013 · Drug interaction. A 40-year-old woman receiving atorvastatin developed rhabdomyolysis associated with concomitant ingestion of grapefruit juice. The woman, who had hyperlipidaemia and iron-deficiency anaemia, was receiving atorvastatin 20 mg/day for 3 years. Recently, she had started drinking 1-2 glasses of grapefruit juice a day [ duration of ... Statin interactions: Grapefruit and pomegranate can be a "dangerous mix" (Image: Getty Images) Also, "do not drink grapefruit juice if you're taking the statin simvastatin", warns the NHS ...1. The pharmacokinetics and pharmacodynamic of concomitant administration of atorvastatin with bergamottin were investigated perspectives to reveal the potential herb-drug interaction between these two drugs.2. The hyperlipidemia-induced Wistar rats received atorvastatin with or without bergamottin (2.5 mg/kg). What are the risks of grapefruit and statin interactions? People who eat grapefruit or drink grapefruit juice while taking atorvastatin, lovastatin, or simvastatin are more likely to experience side effects of their medication. Women aged 65 and older are especially likely to develop side effects from the combination.Find patient medical information for atorvastatin oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. ... Avoid eating grapefruit or ...Aug 26, 2021 · This interaction is typically mild — your pharmacist or healthcare provider may be able to tell you if these need to be separated. A common, well-known interaction is with grapefruit juice and statin medications — like atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Mevacor) — which are used to lower cholesterol. Grapefruit, drug interactions November 1, 2010 The potency of some cardiovascular and other drugs is affected by grapefruit, pomelo, and other juices. Some of the most common drugs affected by grapefruit are listed below. To continue reading this article, you must log in.The most discussed interaction is the grapefruit. Grapefruits can slow or halt some liver enzymes and should generally be avoided while taking statins. This includes grapefruit juice and other derivatives of grapefruits. ... Lee, Jonathan W., et al. "Grapefruit Juice and Statins." The American Journal of Medicine, vol. 129, no. 1, 2016, pp ...Consider if levitra 20 mg generic know the chain such as levitra coupon can be glass in 10% of the collecting ducts, Levitra may also be used for purposes not listed in this medication guide.When grapefruit and simvastatin are taken together, blood levels of the drug increase by 260 percent ( Lee, Morris & Wald, American Journal of Medicine, Jan. 2016 ). When taken 12 hours apart, as your doctor recommends, blood levels go up by 90 percent. Enjoying grapefruit once or twice a week probably won't have a lasting effect.In fact, grapefruit can increase the risk for statin side effects by up to 5 times! Is grapefruit unsafe with all statins? There is hope if you really enjoy grapefruit. Not all statins have the same dangerous interaction with grapefruits. The trouble only occurs with atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Mevacor).Some drugs, like statins used to lower cholesterol, are broken down by enzymes. ... With most drugs that interact with grapefruit juice, "the juice lets more of the drug enter the blood ...It is also smart to ask your pharmacist about possible drug interactions if you regularly enjoy grapefruit or grapefruit juice. Types of common medications that are known to interact with grapefruit include: Abnormal heart rhythm (arrhythmia) medications. Anti-rejection medications. Anti-infection medications. Blood pressure medications.Nov 29, 2012 · ABC News says that as little as "one grapefruit or one 8-ounce glass of grapefruit juice can cause an effect that may last more than 24 hours," and reports the following A-Z partial list of medications believed to interact with grapefruit: Alfentanil (oral) Amiodarone. Apixaban. Atorvastatin. Buspirone. Other medications that interact with grapefruit. Here are some of the common medications that people with diabetes and heart disease may take, which interact negatively with grapefruit: Statins (cholesterol drugs): lovastatin (Mevacor®), atorvastatin (Lipitor®), simvastatin (Zocor®), simvastatin/ezetimibe combination (Vytorin®)When grapefruit and simvastatin are taken together, blood levels of the drug increase by 260 percent ( Lee, Morris & Wald, American Journal of Medicine, Jan. 2016 ). When taken 12 hours apart, as your doctor recommends, blood levels go up by 90 percent. Enjoying grapefruit once or twice a week probably won't have a lasting effect.Dec 17, 2020 · Concomitant intake of large quantities, more than 1.2 liters daily, of grapefruit juice is not recommended in patients taking atorvastatin calcium [see Drug Interactions (7.1)]. Discontinue atorvastatin calcium if markedly elevated CK levels occur or myopathy is diagnosed or suspected. Grapefruit juice interacts with many medications such as Lipitor, Over 40 of these can cause serious effects [].Drugs that react with grapefruit are all taken by mouth and require a relatively low dose to have an effect [].Grapefruit juice can increase the blood concentration of some drugs and decrease the concentration of others, diazepam ... Statins Abstract: The statins are widely used worldwide to reduce risk for cardiovascular events in both the primary and secondary prevention settings. Although generally quite safe, the statins can be associated with a variety of serious side adverse effects, including myalgia, myopathy, and changes in plasma enzymes of hepatic origin.Grapefruit juice does not interact with other "statins" including pravastatin (Pravachol), fluvastatin (Lescol), and rosuvastatin (Crestor). Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)Interaction Rating: Major Do not take this combination. 10l_1ttl